GMOs, Yes!

By Jon Entine

Friday, May 08, 2015

Do you like Ruby Red grapefruits? How about Italian pasta? Vietnamese rice? Ever try an über-delicious Osa Gold pear from Japan?

If you are a food devotee, and pride yourself on ‘going organic,’ you could more than likely pick up samples of each of these specialties at your local Whole Foods. And that way you could avoid the ‘taint’ of eating food that might have come in contact with ‘dangerous’ GMOs. You know, foods created in laboratories. By whitecoat scientists. Untested and unlabeled. Ticking health time bombs. Frankenfoods.

Oops. Better change your menu, because those four foods, often sold as organic, were created in laboratories. By scientists. In white coats, more than likely.

In fact, almost none of our foods that we eat today is the product of Nature’s way. Consider corn, which supplies about 21 percent of human nutrition across the globe. Scientists now believe it is the descendant of an ancient wild grass with relatives in Mexico today known as teosinte. It had kernels all right: inedible black ones that could crack your teeth. That was before humans intervened to bend Nature.

Beginning about 10,000 years ago, it is believed, our ancestors set up field labs—yes that ugly word—to randomly experiment on this odd grass with hard buds. Through trial and error, cobs became larger and slightly more edible over the centuries, and with more rows of kernels, eventually taking on the form of modern maize. Modern sweet corn yields 100 times more than teosinte, a testament to genetic modification.

Modern bananas, eggplant. Brussels sprouts, and almost every food we eat, have been generically altered in some way by humans. Over the centuries we’ve genetically modified thousands of foods. Scientists at the International Rice Research Institute developed flood tolerant rice by moving rice genes from an ancient rice variety to modern varieties using marker assisted breeding. The modified rice has led to a boom in yields in flood prone areas.

GMO critics seem comfortable with that kind of genetic manipulation. But when it comes to inserting genes from one species into another, many people go “yuck,” claiming that it is “totally different” than conventional breeding.

Understanding Genetic Modification

Well, it is and it is not. Nature itself has moved genes ‘naturally’ across species lines since the dawn of evolution. And we all carry within us the seeds of our ancestral past, which includes our genetic benefactors: bacteria, viruses, plants, fish, extinct dinosaurs and the panoply of life that we see today. Indeed, we share 30 percent of our genome with the marigold, 60 percent with worms. And 99 percent percent with apes. All life is genetically tied together; we all have common ancestors reaching deep into prehistory. In Nature, genes are just genes; what makes them different is how they are expressed. So moving genes from one species to another is not very radical when one understands the course of evolutionary history.

Let us look at some examples of genetic modification that are different than conventional breeding—genetic engineering. Thirty five years ago, the Hawaiian papaya was facing what many thought was its end game, threatened by the ringspot virus that had first appeared in the 1950s in Oahu, nearly wiping out the entire island’s production. By the 1980s, most farmers and scientists believed the delicious fruit was doomed.

But not Dennis Gonsalves. A local Hawaiian, Gonsalves had grown up with the devastation. While others threw up their hands, he went into the laboratory, working in Hawaii and at Cornell University, where he was a plant pathologist. With government funding, and with major corporations donating the patent rights to facilitate his research, Gonsalves placed a small snippet of “foreign” DNA into the papaya—a virus that effectively inoculated the papaya from the ringspot disease.

“Eeeew,” say GMO critics: a virus injected into food? That is dangerous. That is mixing across species. That is Frankenstein’s work.

Well, it is really not much different than what happens every day in millions of doctor’s offices around the globe. Humans are injected with viruses in vaccines to protect against polio or other diseases. Yes, in theory, getting a vaccine is not much different than genetically engineering a vaccine into a plant. The genetically engineered papaya carries just trace amounts of the virus. In contrast, if you bite into a conventional or organic papaya that is infected with the virus—and many people do because it is not always easily observable—you will be chewing on 10-fold more viral protein, and it will not harm you.

What happened? Gonsalves’ pioneering work rescued a dying fruit and revived a critical Hawaiian industry. Today there is still no other method to control this disease. In fact, 80 percent of all Hawaiian papaya is genetically engineered, and it is eaten in many countries, sold in Costco and grocery stores alike. GMO papaya is perfectly safe, and has been a savior.

Biotech 2.0

The future of genetic engineering, what I refer to as “Biotech 2.0,” will lead to many stories similar to the rescue of the papaya—if GMO opponents are not successful in scaring people away from this technology. A nasty pest, the fruit and shoot borer, feasts on eggplant (brinjal), a staple in some countries like Bangladesh. It has devastated production. Farmers are forced to spray dangerous insecticides as much as twice a day. That is expensive and leads to collateral health problems in workers. The World Health Organization estimates that 300,000 people die every year in Bangladesh and other less developed countries because of the overuse of pesticides.

That is shameful when there are GMO alternatives. To confront this potentially devastating challenge, researchers in Bangladesh partnered with Cornell University to develop Bt brinjal, South Asia’s first GMO food crop. It is not owned or patented by major corporations. It is grown from public sector seeds, developed for distribution to resource-poor shareholder farmers.

Bt brinjal has natural pesticides built in—the kind found in every plant—engineered into it. Pamela Ronald, a distinguished plant geneticist at the University of California-Davis, has spent her career trying to draw on the best sustainable practices of organic and conventional agriculture. As she has explained it, organic farmers in developed Western countries often spray an insecticide, called Bt, that is highly specific to pests but is nontoxic to birds, fish and humans. It is less toxic than table salt. It has been used safely in organic farming for nearly 100 years.

In the organic approach, she noted, the bacteria is grown in industrial fermentation tanks and processed to produce a formulation of bacterial spores that is sprayed on plants. But this strategy does not work well for eggplant farmers in Bangladesh. That is because sprays are expensive, hard to find in Bangladesh, and do not prevent the insect from getting inside the plant.

With genetic engineering, scientists cut the gene out of the bacteria and inserted the bacterial gene directly into the eggplant genome. It works and it is safe; just ask organic farmers.

Bt brinjal has been a huge success—much to the chagrin of the powerful anti-GMO lobby, which knows that its adoption could open the floodgates to new nutrition and health focused public sector GMO foods. To prevent that from happening, they have mounted a vicious public relations effort to scare farmers and the public alike that Bt technology—yes, the one used safely by organic farmers around the world—is somehow unsafe in Asia.

Activists are using what amounts to a “nuclear option,” raising the specter of health fears. Among other nefarious tactics, anti-GMO activist posing as journalists have been telling farmer that their children could become paralyzed from eating Bt brinjal. This parallels the sterility/infertility myth that has been spread about GM crops elsewhere in the world, in particular in sub-Saharan Africa. Bt crops are activists’ worst nightmare: they offer a compelling narrative about how this technology can help the poor.

The exact same technology sweeping through Bangladesh has been used in India, on cotton fields. Introduced barely a decade ago, now upwards of 90 percent of Indian cotton is grown using Bt seeds. It has resulted in a huge jump in output, and just as importantly, a sharp reduction in health problems related to the overuse of pesticides. Bt corn and soybean is widely grown in the United States.

You may have read, from anti-GMO websites or oh so reliable sources like Dr. Oz, that the use of GMOs has unleashed a pesticide tsunami that is sweeping across the plains. Not. According to the USDA, since the introduction of Bt crops in the United States, over nearly 20 years, the U.S. corn farmers have cut their chemical sprays ten fold. It is win-win—unless your goal is to sabotage the technology.

 The Naturalist Fallacy

So the idea that someone should consider rejecting genetically modified food because scientists are “playing God” by “fiddling with Nature” is—let us use a gentle term—hogwash. Such facile comments are examples of what is called the “naturalist fallacy”—the silly belief that organic foods are somehow more “natural” than conventional foods, and superior/more nutritious/safer than genetically modified alternatives.

Let us return to the story of our organic basket of “natural” goodies. Brace yourself: Unlike the foods grown from genetically modified seeds, in which scientists precisely modified one or two genes, then tested the heck out of them for safety and allergenicity at a cost sometimes reaching $250 million dollars, these foods were created by bombarding seeds with radiation and corrosive chemicals to create tens of thousands of random mutations. It took scientists 6 years and tens of thousands of failed random experiments until they lucked upon the mutant mess that we now lovingly embrace as juicy red grapefruits.

The process is called mutagenesis. Radiation breeding was discovered in the 1920s, first using gamma rays and then X-rays. It often takes place in laboratory Atomic gardens, and seeds have been sent into orbit in order to expose them to more cosmic radiation. An array of chemical mutagents has also been used, including Ethyl methanesulfonate and Dimethyl sulfate. (Yummy!)

Have these lab-created mutants with tens of thousands of untracked modified genes ever been tested? No. Are they labeled? No. In fact, 3,200 ornamental plants and common grains, fruits and vegetables created through mutagenesis are eligible to be sold as organic.

Makes the Frankenstein argument sound kind of silly, yes?

Anti-GMO crusaders say you need at least a century of testing to confirm that any lab induced food changes are safe. If their logic has any validity—that precisely altering and tracking 1 or 2 genes (or no genes in the case of the most modern genetic modification techniques like CRISPR and gene editing) can have dangerous and unknown consequences—then you will surely keel over dead from consuming organic Tuscan noodles. Do you really want to risk turning yourself into a ticking time bomb by eating foods mutagenetically created in breeding laboratories?

Maybe, just maybe, what you are hearing about GMOs and food safety are not exactly accurate or in context.

GMOs=Evolution=Climate Change=Vaccine Safety

It is odd being asked to “defend” crop and animal biotechnology. (As shorthand, I will use the term GMOs, representing “genetically modified organisms,” although that’s a misleading acronym, as I’ll later address). Few people except extremists like the Organic Consumers Association are challenging the safety of more than 200 remarkably effective and safe GMO drugs, including a breakthrough Ebola treatment developed by genetically engineering a tobacco plant. The process to make them is identical, so in a rational world, all the opponents GMO foods would be up in arms about the use of GMO insulin, safely used for more than two decades now.

But food is viewed differently, perhaps because we engage with it every day, multiple times a day. We are all experts about food, so we think. This fact partly explains why when it comes to food, people get a wee bit irrational. People may have more superstitions and taboos about food than about practically anything else they experience.

Yes, there is a vigorous public discussion over GMOs. Yes, the thought of tinkering with our food in a lab—unaccountable scientists mixing steaming flasks—conjures up visions of soylent green and grotesque deformities. Let us acknowledge it; no one wants “technology” for desert. The thought of GMO foods is not appetizing!

We will return to that faux narrative later. But it is important to settle the issue of whether GMOs are safe. It turns out that a huge chasm separates the views of the average Joe and Jane from mainstream scientists.

Simply said, mainstream science has reached the consensus conclusion that GMOs are safe—at least as safe as conventional and organic foods, and most likely safer. In sharp contrast to public opinion about GMO safety, 89 percent of American scientists polled believe genetically modified foods are safe.

That was the most eye-opening finding in a Pew Research Center study on science literacy undertaken in cooperation with the American Association for the Advancement of Science (AAAS), and released in January. The survey represented a sample of 2,002 adult citizens and 3,748 scientists, all members of the AAAS. In contrast, PEW found that some 57 percent of Americans questioned the safety of GM foods, although the opinion of many of those skeptics was very weak, and their understanding of what GMOS are was often thin or wrong.

Startlingly, the overwhelming scientific consensus on GMO safety exceeds the percentage of scientists, 88 percent, who believe humans are driving climate change. And it is about equal to the percentage of mainstream scientists convinced that humans are the product of evolution, rather than Creation, and vaccines do not cause autism. Those conclusions all garner about a 90 percent consensus.

Yes, you can find divided opinion among scientists on each of those issues. One global warming denying website carries signatures from 31,000 scientists who have signed an online petition saying there is “no convincing evidence” that “humans can or will cause global warming.” Anti-evolution ideologues boldly, if ignorantly, assert, “defenders of the ‘Evolutionary Consensus’ could benefit from more fact checking.”

Similarly, a fringe group of well-known campaigning scientists and activists leaders known as the European Network of Scientists for Social and Environmental Responsibility challenges the consensus on GM technology. Gilles-Éric Séralini and his colleagues and allies lead ENSEER, as it is called. Séralini’s discredited 2013 study attempting to link GM foods to cancer in rats was retracted before being republished in an obscure pay-for-play journal with no peer review.

“As scientists, physicians, academics, and experts from disciplines relevant to the scientific, legal, social and safety assessment aspects of genetically modified organisms (GMOs), we strongly reject claims by GM seed developers and some scientists, commentators, and journalists that there is a ‘scientific consensus’ on GMO safety,” ENSEER states on its website.

Its petition has a few hundred signatures, none from prominent independent researchers. That is no surprise. The statement veers sharply from mainstream science—independent academic and government researchers with no ties to the biotechnology industry.

 Global Consensus on GMO Safety

More than 100 of the world’s independent science organizations have endorsed the safety and sustainability of GM food technology. And they did not just reach that conclusion out of a vacuum. A meta-study of more than 1,700 peer-reviewed studies by independent Italian university scientists found no evidence that GMO crops produce adverse affects in humans or livestock. It is estimated that there have been more than 3,000 safety and environmental studies on GMOs, with more than two-thirds performed by independent researchers.

It is this overwhelming evidence that has led to consensus conclusions on GMO safety. Here are statements issued on both climate change (CC) and GM technology by some of the most prominent global organizations:

American Association for the Advancement of Science

CC: “The scientific evidence is clear: global climate change caused by human activities is occurring now, and it is a growing threat to society.” (2006)

GMOs: “The science is quite clear: crop improvement by the modern molecular techniques of biotechnology is safe.” (2012)

National Academies of Science (USA)

CC: “The scientific understanding of climate change is now sufficiently clear to justify taking steps to reduce the amount of greenhouse gases in the atmosphere.” (2005)

GMOs: “Genetic Engineering … poses no health risks that cannot also arise from conventional breeding and other methods used to create new foods.” (2004); “An analysis of the US experience with genetically engineered crops shows that they offer substantial net environmental and economic benefits compared to conventional crops. … Generally, GE crops have had fewer adverse effects on the environment than non-GE crops produced conventionally.” (2010)

European Commission

CC: “There is unequivocal evidence that the Earth’s climate is warming. … The consensus among climate experts is that it is extremely unlikely that the main cause of recent warming is the ‘greenhouse gases’ emitted by human activities.” (2012)

GMOs: “The main conclusion to be drawn from the efforts of more than 130 research projects, covering a period of more than 25 years of research and involving more than 500 independent research groups, is that biotechnology, an in particular GMOs, are no more risky than conventional plant breeding technologies.” (2010)

International Science Academies

CC: “Climate change is real. … It is likely that most of the warming in recent decades can be attributed to human activities.” (2001)

GMOs: “GM technology has shown its potential to address micro-nutrient deficiencies [in developing nations]. … GM technology, coupled with important developments in other areas, should be used to increase the production of main food staples, improve the efficiency of production, reduce the environmental impact of agriculture, and provide access to food for small-scale farmers.” (2001)

Consensus statements alone should not necessarily convince skeptics. Experts can be wrong. (Anti-GMO campaigners like to claim that American medical establishment widely endorsed the safety of cigarettes into the 1960s, but that is a fabrication. There were official statements by mainstream science groups citing adverse health effects dating to the 1920s. And let us hope global science is a tad more sophisticated than it was a half century ago.) Consensus statements are important, however, because they represent the views of researchers familiar with the intricate science of genetics and abreast with the latest research.

Can We Trust U.S. Scientists or Regulators?

One of the central claims of anti-GMO activists is that you cannot trust claims that GMOs are safe because they are not aggressively regulated. On its website, the Union of Concerned Scientists (UCS), whose anti-GMO policy was crafted by Doug Gurian-Sherman, eased out of his position at UCS last year, claims: “It is … an exaggeration … to state that there are no health risks associated with GE. … not enough is known; research on the effects of specific genes has been limited—and tightly controlled by the industry.”

That’s a familiar meme: invocation of the industry-government axis. Consumer Reports crossed over from independent critic to hard-edged activist on the GMO issue when it hired Michael Hansen, a dedicated ideologue, as its senior scientist more than a decade ago. Like UCS and many other advocacy NGOs, it attempts to sow doubt about the North American regulatory structure.

“You may be surprised to know that the federal government has not mandated that genetically modified organisms be proved safe before they’re used in your food,” claims a recent CR blog post. Testing is “voluntary,” they say, which means the public is not protected.

In fact, while the word “require” is not found in Food and Drug Administration regulations, there is no question that it requires all foods placed on the market in the United States to be safe. Violators are subject to criminal penalties. The FDA relies on tests from submitters for all foods, not just GMOs; this way, it is up to the submitter to pay for the proper testing, which the FDA approves or disapproves, or sometimes asks for more information.

In an interview with Nathanael Johnson of Grist, even Hansen—one of the original signatures of the “no consensus” document circulated by ENSEER—could not identify a single GMO submission that did not include extensive safety data.

“Here’s the deal,” wrote Johnson in his excellent multi-part series on GMOs that in a manner of months transformed the environmental website Grist into a reliable resource for those seeking independent analysis on this technology. “The process is technically voluntary, but in practice, absolutely everyone does ‘volunteer.’ That’s because the FDA can stop any food (GM or otherwise) from going to market. It would be incredibly foolish for a company to spend a lot of money on a new breed of plant while thumbing its nose at the agency.”

“To believe these claims, means you’re saying the regulatory system is corrupt, and incapable of discerning science,” Bruce Chassy, Professor Emeritus of Food Safety and Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign told me.

The conspiratorial mindset infects many anti-GMO critics. They see a vast network of subterfuge: university scientists and regulators, directed by the giant hand of Monsanto to “control” the world food supply. Utterly absurd. For starters, Monsanto is not even that large; its annual revenues are about on par with Whole Foods. It sells about one quarter of the world’s seeds, with seeds being only a tiny fraction of the world food system. This is the kind of black-hat view of the world that captures the imagination of fevered teens. But the anti-GMO industry seems locked in perpetual adolescence.

GMO Regulations

Here is a more granular look at the regulatory hurdles—far too high say many scientists, with barriers set up based more on fear than promoting safety—for GMO crops in the United States.

Biotech crops go through rigorous testing for several years before they are ever put on a farmer’s field. In the United States, there are nine steps in the process that usually take 7 to 10 years to complete, which is far more rigorous process than any conventionally derived food ever goes through.

Any notion that conventional and organic foods are automatically “safe” is a dangerous myth, as anyone familiar with the story of the Lenape potato can attest. Conventionally developed in the 1960s for the snack business, it made a damn fine potato chip. Unfortunately, it was kind of toxic, and was withdrawn. This idea, perpetrated by activists, that GM plants are uniquely at risk of producing unexpected side effects, is just plain wrong. In fact, because of rigorous testing of GM crops, it is far more likely that an allergenic or unintentionally toxic new conventional/organic food would get to market than a GM variety—which is why many global science agencies contend that GM crops are actually “safer” than their counterparts.

In the United States, the USDA/Animal and Plant Health Inspection Service is responsible for ensuring that any released organisms are safe and will not pose serious risks for the environment, whereas the EPA evaluates the safety of transgenic plants containing potential allergens. They consider where and how the protein is produced in the plant and its potential to be toxic to humans and other organisms.

“Regulatory review from the USDA and the EPA is mandatory in every sense—there’s nothing even legalistically voluntary about that,” Johnson noted in Grist. All agricultural products must pass field-testing required by the USDA, and allergen testing required by the EPA.

Before pesticides can be marketed, the EPA considers:

– Risks to humans

– Risks to non-target organisms and the environment

– Gene flow potential

– Insect resistance management plans

The EPA also requires certain tests to be conducted to identify any risks to humans and the environment:

– Identification of new genetic material and all new proteins

– Mammalian toxicity testing of all new proteins

– Comparison of new proteins to known toxins and allergens

– Toxicity testing on birds, fish, earthworms, insects such as bees, ladybird beetles, and lacewings

– Toxicity testing on insects related to target insect pests

– Length of time required for the new proteins to degrade in the environment

The development of a transgenic plant requires researchers to meet with one or more regulatory agency (EPA, USDA/APHIS, or FDA) to discuss the outline of the projects and decide which studies will be necessary to ensure safety of the end product. Throughout the study the developer sends the data of the ongoing research to the appropriate agency.

For many biotech crops, the product then goes through a deregulation process in which the USDA/APHIS reviews the data received from the developer and decides whether or not the transgenic plant causes a negative outcome in the environment by genetically crossing with native species or out-competing them. They also try to ensure that the transgenic plant does not have any negative effects on wildlife, and does not become a “super-weed.” The overall goal of the regulatory agencies is to ensure that biotech crops are as safe as their non-genetically modified counterparts.

Long-Term Studies?

What about the claim made by organic activist scientist Charles Benbrook and repeated endlessly by anti-GMO activists that there have been few or no long-term studies? That’s false. The independent database GENERA, set up at the University of Wisconsin, lists more than three-dozen examples of multi-year studies showing no unusual health consequences from consuming GMOs.

A recent updated review published in December 2013 of 33 studies—17 long-term and 16 multigenerational studies—by a team of scientists including Chelsea Snell and Agnès Ricroch found, “Results … do not suggest any health hazards … and there were no statistically significant differences within parameters observed.”

And a recent review of 29 years of livestock health and productivity statistics published in the Journal of Animal Science—looking at relevant data from both before and after the introduction of genetically engineered feed and covering more than one billion animals—concluded that GM feed is every bit as safe and nutritious as non-GM.

The data review, overseen by University of California-Davis geneticist Alison Van Eenennaam, is unusual because of the vast trove of records examined. No, they were not just “industry data,” but mostly records provided by farmers and the U.S. government.

Van Eenennaam reviewed heath parameters including somatic cell count (SCC—an indicator of mastitis and inflammation in the udder) and pre and post mortem condemnation records in cattle, as ill cattle cannot be approved for meat, as well as mortality in the poultry industry.

“It should be noted that if animals are sick they do not grow well, and growth rates have not be affected by GMO feed,” Van Eenennaam told me.

The paper also summarized the results of two thorough multigenerational studies that examined the long-term effects of feeding a GMO corn variety to food-producing animals, specifically, a German study in dairy cattle and an Irish study in pigs that included several papers looking specifically at health indicators. These independent studies were notable in that they included appropriate control animals consuming isogenic non-GE lines of corn, and both comprehensively examined a range of phenotypes and indicators of health using sophisticated techniques including histopathology and hematological analyses. These papers found that transgenerational consumption of these GMO corn diets was not detrimental to animal health.

But “It is not a controlled study,” claim critics. Of course not. It is impossible and unethical to do a three-decade study, on animals, let alone on humans. It’s also useless; those who claim that there are no “long term” studies on GMOs (not true; there have been dozens) and then object when three decades of data do not confirm their prejudices are apt to get belligerent.

It should be underscored that animal feeding studies are the basis for evaluating the safety of GMO crops. The data also show that GM feed is safe and nutritionally equivalent to non-GMO feed. There was no evidence of any health risk to the animals and no evidence to suggest any health effect on humans who eat those animals.

The practical fact is that after 30 years of experience using GM crops as animal feed—and for the record, even anti-GMO Europe uses GMO feed—there is not one documented case of any health problems. Invoking the “precautionary principle” and claims of possible future unknowns or unintended consequences are nothing more than ideologically fashionable ways of playing the fear card.

Have there been a few studies of lab animals that hint at the potential for potential problems? Absolutely. But they number a few dozen at most, set against thousands that have found no adverse issues.

One animal GMO corn-glyphosate study by Séralini garnered wide attention with pictures of grotesquely distorted rats, but it was retracted because of its many methodological flaws and misleading conclusions, after which it was republished without peer review. But think about it: If his data were credible and 80 percent of food in the United States was poison, his sure-to-be Nobel Prize winning paper documenting this horror would not have had to be published in the Environmental Sciences Europe—an obscure ‘pay for play’ journal with zero gravitas. Good journals would not, did not, accept the tortured statistics, missing controls and over-interpretation of limited data; Seralini had no place else to go literally except to buy his way into a dicey publication.

There is not one example in the publishing record of a study purporting to find health or safety dangers originating from GM foods that has been replicated in an independent, peer-reviewed journal. Not one.

In the absence of serious GMO safety concerns, activists and fellow traveler skeptics in the “liberal” community are reduced to raising side issues, such as blaming biotech crops (read: Monsanto) for the rise of so-called “superweeds.” Invoking Little Shop of Horrors imagery, they claim that the use of glyphosate—an extremely mild pesticide that homeowners can buy at one’s local Do It Center—paired with GMO seeds is courting ecological disaster. Anyone writing that is not a farmer or geneticist. Glyphosate preceded the GMO revolution by 15 years and has led to a dramatic reduction in toxic spraying per acre.

But what about “superweeds”? Let’s dump the scare jargon: superweeds are not ‘super’ in any real sense of the word; they are just weeds that have evolved to evade a particular weed management strategy. If you have ever seen a dandelion so short that it has almost no stem, you have seen a superweed. That dandelion’s super power is crouching down, so that lawnmowers cannot get it before it goes to seed.

Crop losses before harvesting average 35 percent worldwide currently. What would those losses be without pesticides like glyphosate? More like 70 percent, say agricultural experts.

Periodic resistance to pesticides has been growing for about 40 years—in parallel with the rise of large-scale farming, both conventional and organic. Let’s keep this in context: there are 150 weeds overall that resist some kind of herbicide; one, and far down the list of risky, is glyphosate. It has become the bogeyman for those with no working knowledge of agriculture who want to flog GMOs by proxy.

Will There Be Next Steps in the GMO Revolution?

As I hope I have made clear throughout, the concept of GMOs as a “category” of food to be embraced or rejected, in whole or in part, is silly from a science point of view. I used the term “GMOs” throughout this essay as a concession to the popular vernacular, but the term is both meaningless and misleading. GM is a process. Each GM crop is unique.

There exists a range of viewpoints about whether genetic engineering promotes deleterious farming and ecological practices—the so-called dangers of corporate controlled industrial agriculture; or the over-production of commodity crops that some say contribute to our collective weight problem. Those are important issues; they just don’t apply specifically to GMOs.

The central issue that you must assess is the safety of GMO foods. In evaluating GMOs, we need to focus not just on evidence in any one study, but also on the mounds of accumulated evidence and the process of science:

•    Reproducibility of studies

•    Skepticism of one-off research

•    Weight of evidence

•    Willingness to revise theories in the light of new, reproducible data

In that context, many of those who maintain that GMOs are potentially harmful, while sincere for the most part, are engaging not in science but in politics. Let me give you an example. Anti-GMO NGOs often claim that the safety of genetically engineered foods cannot be assured because Big Ag funds most GMO research and there have been almost no long-term safety studies.

I fear inquisitive consumers who read attacks on GMOs and believe this will be left feeling scared, mistrustful and conflicted about our farmers and food system. Vigorous debate over the future of food is healthy, but this obsession with GMOs has driven reasonable discourse into the ditch.

The world economy hinges on innovation. Regulation that prevents The Next Big Thing is truly a lost opportunity—many once-touted biotech innovations have been killed in the crib by over-regulation: Triffid flax, NewLeaf Potatoes and almost the entire field of transgenic animals—possibly even AquaBounty’s GE salmon, which languishes in regulatory no-man’s land because of political intervention from the White House.

No longer can we expect breakthroughs in GE biorational pesticides, microorganisms to clean up toxic spills or transgenic animals.

Do we want to continue to thwart startups or university research projects? Or should we link science to regulatory sanity and revise the approval process to reflect what we have learned over decades of research and years of experience and trillions of meals?

Used appropriately, genetic engineering is a fantastic tool—to create new life-saving drugs and encourage cutting edge ecologically based farming technique. We must increase food output to meet a burgeoning world population that is also becoming more affluent. No tools in our toolbox should go to waste.

In a recent TED Talk, Professor Ronald summed up the crisis before us quite cogently: “What scares me most about the loud arguments on plant and animal genetics and the spread of misinformation and the demonization and fear campaigns is that the poorest people, who need the technology the most, might be denied access to modern scientific innovations because of the vague fears and prejudices of those who are privileged to have enough to eat.”